Maybe a different religion, or especially political beliefs seems to be a big deal-breaker. Do you still find it worthwhile to keep them in your life?
I do. I have e.g. Christian Conservative friends, and Atheist Liberal ones, etc. I enjoy each one for what they are. I mean, nobody is perfect! (like me 😁)
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The two extremes seem more similar to each other than most people seem to want to admit - to me anyway. But I respect anyone’s opinion to not see it that way.
More to the point, having changed my own beliefs multiple times throughout life, I suppose I just see others who are still on some “other side” as being more like me, or at least past me. We are all just wrong in different ways.
Yes, I get that people are going to die. Even so.