When old cells are damaged they are at risk of turning into cancer. Many of them rather die (apoptosis) or turn senescent (in that case they can’t produce melanin to make color of hair).
Killing should work for many tissues, especially those whose cells still divide. But for some tissues it is problematic. Killing senescent cell from muscle would make the whole muscle fiber to break. Killing senescent neuron could lead to loose of some cognitive or other function. So part of dealing with senescent cells is to modulate them so they do not vomit senescence associated secretary phenotype (SASP) which is quite annoying to other cells. Ultimately, we could rejuvenate senescent cells so they would work properly, but that seems much harder than other options.
Any cap here with a good explanation?
When old cells are damaged they are at risk of turning into cancer. Many of them rather die (apoptosis) or turn senescent (in that case they can’t produce melanin to make color of hair).
Oh yeah, that’s a good explanation
While it’s not a good trade you’d rather have gray hair if it meant you didn’t get melanoma
Why not avoid both
That’s the intention, but…
Isn’t the idea just to slowly kill them?
Killing should work for many tissues, especially those whose cells still divide. But for some tissues it is problematic. Killing senescent cell from muscle would make the whole muscle fiber to break. Killing senescent neuron could lead to loose of some cognitive or other function. So part of dealing with senescent cells is to modulate them so they do not vomit senescence associated secretary phenotype (SASP) which is quite annoying to other cells. Ultimately, we could rejuvenate senescent cells so they would work properly, but that seems much harder than other options.
No cap available, apparently