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Joined 3 years ago
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Cake day: June 11th, 2023

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  • I’m really confused by your post. The questions don’t seem to match eachother’s. I feel you have not made clear the specific use case you’re troubleshooting.

    I am an inexperienced knob on Homeassistant and home automation, that lurks here out of curiosity and to catch some easy crumbs left around.

    But, I feel that I know enough about central heating, radiators and thermostats to justify commenting.

    The central heating boilers, pretty much always, just work as on-off. With some internal (boiler) logic on safety limits, like the working temp of the radiator fluid.

    Thus your obvious question has an obvious answer. The way to have the main thermostat sending a heating request is to lower it’s setpoint temp.

    At the same time, the TRVs are supposed to limit/moderate the lowness of the main thermostat setpoint, i.e., to moderate the way in which the main thermostat activates the boiler ‘too soon’. And TRVs allow you to adjust the comfort of each room (as long as the main thermostat is already requiring the boiler to be on).

    As for the presence sensors. Radiators take a long time to heat a room. Like dozens of minutes. If the presence sensors work as their name suggests, I feel they are not a good match with radiators. Plz teach me!! How do these work? What happens when you are sleeping, or when siting, reading, or watching TV, or in the computer.

    “I’ve heard about central heating systems not enjoying a fully thermostatic valved circuit.”

    ‘Enjoy’? Ehh, the pump (usually a part of the boiler) and the tubing that make the radiator’s fluid circulate, from the boiler around the house and around the radiators, they are not contructed/designed to have the circuit closed. 100% closed. Thus the recomendation not to put TRVs in all radiators - which could potentially all close off at the same time and damage the circuit (with overpressure). The recommendation is to have at least one radiator with it’s manual valve always open. The recommendation is also improved to have this radiator in the bottom of the house or the closest to the boiler, instead of a radiator in the top floor bathroom where you’ve left open the window to let out the moisture or something.

    Again, what is it really what you want to solve?








  • After sparing this paper a fair bit of attention I feel I’ve wasted it.

    Nowhere in the paper could i find in what conditions the test samples were kept during the experiment. This is pretty basic stuff. At this stage I’d wage sloshing was the issue.

    Reading this part of the methodology:

    "2.2 Initial sperm analysis

    After liquefaction…

    [Two paragraphs later, in the same section: ] After this first analysis, the 15 sperm samples were split into two fractions. All the samples were exposed to ‘Parabolic flight’ (split 1) and to…"

    Did they liquefied the samples and tested like that? Whaa?

    The “After this first analysis” should not be in the “2.2 Initial sperm analysis”. It just shouldn’t!

    Then I think “15 sperm samples were split into two fractions”. … “the samples were exposed to ‘Parabolic flight’ (split 1)” — splits, fractions, what a mess!! At this stage I’ve wasted enough.

    The paper should be retracted, the reviewers spanked and the editor fired.









  • Abstract

    Most of the widely used vaginal lubricants in the U.S. and Europe are strongly hyperosmolal, formulated with high concentrations of glycerol, propylene glycol, polyquaternary compounds or other ingredients that make these lubricants 4 to 30 times the osmolality of healthy vaginal fluid. Hyperosmolal formulations have been shown to cause marked toxicity to human colorectal epithelia in vivo, and significantly increase vaginal transmission of genital herpes infections in the mouse/HSV model. They also cause toxicity to explants of vaginal epithelia, to cultured vaginal epithelial cells, and increase susceptibility to HIV in target cells in cell cultures. Here, we report that the osmolality of healthy vaginal fluid is 370 ± 40 mOsm/Kg in women with Nugent scores 0–3, and that a well-characterized three-dimensional human vaginal epithelium tissue model demonstrated that vaginal lubricants with osmolality greater than 4 times that of vaginal fluid (>1500 mOsm/Kg) markedly reduce epithelial barrier properties and showed damage in tissue structure. Four out of four such lubricants caused disruption in the parabasal and basal layers of cells as observed by histological analysis and reduced barrier integrity as measured by trans-epithelial electrical resistance (TEER). No epithelial damage to these layers was observed for hypo- and iso-osmolal lubricants with osmolality of <400 mOsm/Kg. The results confirm extensive reports of safety concerns of hyperosmolal lubricants and suggest the usefulness of reconstructed in vitro vaginal tissue models for assessing safety of lubricants in the absence of direct clinical tests in humans.



  • Yes!

    My Xiaomi Redmi 11 keeps telling me the Calculator can’t use the network (why?) and keeps asking me to accept the privacy policy.

    Also the app wallpaper - the one that changes the locked screen background image (important complex stuff /s) - also keeps asking me to accept the privacy policy.

    And, as far as my reading of the policy goes, these privacy policies are just the one, it’s not a different one for each app.