I turned the “safe search” filter off so I can really get all the answers.

From my research, it appears that being tied up and naked is her weakness. She seems to be in a lot of distress, so much so they typically have to use some sort of gag in her mouth to prevent her screams of agony.

Sometimes the villains incorporate machines with wands on the end? Not sure if that is part of the process? More research is required.