Manufactured under such circumstances just means that it’s been altered in such a way that nature is either unlikely to or unable to. It’s not so much as it’s at odds so much as they are two distinct processes one is the simple mechanism of the universe doing its thing while the other is a mind inflicting it’s will, while life may be a consequence of thermodynamics we can still tell a burrow from aeons past from a simple rock which the wind has blasted through.

Also this is a matter of philosophy which has the potential of causing first fights amongst anthropologists. Which is what makes it fun. Also there is probably no good answer since it is as much derived from an individuals world view than anything else.