Speaking as a trans woman: This meme in particular? Just seems like lighthearted fun, using a joke to praise somebody for being a good person.
But sometimes people take it too far, and the limit for me is when it’s treated like there are zero exceptions, all men are bad.
I didn’t draw that line arbitrarily. I have lived experience that shows the “all men are trash” crowd are far less likely to treat me as a woman, and more likely to view me as a now vulnerable man who they have an opportunity to take revenge on. Things like laughing at me for having problems they’d be supporting other women for. My mom used to have a friend like that, who laughed and gave me the classic “welcome to being a woman” every time I brought up things like not being able to go home for a while one day because a car tried to follow me there, or when disruptions in my hormone treatment lead to pain and emotional instability.