Again, adverse effects doesn’t mean death, the fact that the description you posed has that last sentence is the alarmist thing and only applies to certain drugs, of course.
The difference in absorption rates between oral and rectal administration can be as much as double or triple or more in some cases. For example I remember reading a study from the 70s or 80s on methylprednisolone. The absorption rate orally was about 90%, but rectally was only around 35% likely due to bacteria in the rectum decomposing the drug before it could make it into the blood.
So, over the long term the difference in dose could have a significant impact on health. Getting 3 times more or less of any drug, even something relatively safe, will likely mean “adverse effects”. With estradiol this could mean greatly increased side effects for overdose like nipple soreness or mood swings, or greatly decreased effect for underdose meaning testosterone takes over again and hair loss and body hair growth restart. These are “adverse effects”, but are not likely to be deadly, but still considered overdose/underdose.
I was just chatting with some people about how I’ve discovered how bad habit and conditioning affect neurotypical people. This was in the context of visual, audio, and other gender cues that cause NT people to misgender trans and non binary people. I had recently discovered how the gender conditioning can make it difficult for NT people to change when things are automatic in their brains. They aren’t used to having to concentrate to remember words like i do, so they don’t have that easy place to inject conscious decisions.
So yeah, there are some things we are superior at and if NT people would just accommodate our disadvantages, our advantages could benefit them. But the current political atmosphere is isolationist and individualism, so they want everything to benefit them since they can’t stand to collaborate to get the benefits we offer.