these people are full of shit. sofosbuvir contains single fluorine atom in such a place that its introduction requires either hydrogen fluoride (also as NEt3.3HF) or DAST (or other very friendly reagents like Xtalfluor-E) and even then, synthesis sucks balls as in has low-to-medium yield (15-50%) and requires extensive purification. you do not, under any circumstances, fuck around with hydrogen fluoride in your garage
these people are full of shit. sofosbuvir contains single fluorine atom in such a place that its introduction requires either hydrogen fluoride (also as NEt3.3HF) or DAST (or other very friendly reagents like Xtalfluor-E) and even then, synthesis sucks balls as in has low-to-medium yield (15-50%) and requires extensive purification. you do not, under any circumstances, fuck around with hydrogen fluoride in your garage
relevant patent https://worldwide.espacenet.com/patent/search/family/051842422/publication/WO2016066283A1?q=pn%3DWO2016066283 first few pages for literature review, around 97-102 for procedures. these sub-50% yields are already heavily optimized
of course it was on hn
Yes one of the !!fun!! chemicals.