According to two US officials cited in the report, two or three people on board are believed to have been killed.
If confirmed, the strike marks the eighth US strike against suspected drug boats since 2 September - but the first in the Caribbean.
The BBC has contacted the White House, Pentagon and State Department for comment.
In a leaked memo recently sent to US lawmakers, the Trump administration said it determined it was involved in a “non-international armed conflict” with drug-trafficking organisations.
At least 34 people have been killed in the American strikes on alleged drug boats, including a recent strike on a semi-submersible vessel in the Caribbean.
Two or three people believed to have been killed…
So we don’t know how many people were on the boat, whether they were killed, injured or what… But by God damn we know there was 600,000 kilograms of cocaine on that boat, along with 72 ounces of weed in a box under the pillowcase in the cabin next to two Tylenol in the night stand.
Any commander involved in this is a murderer, plain and simple.
2 less Tylenol hitting the streets is all you need to worry about.