- Chris Hemsworth: Thor
- Vanessa Kirby: Invisible Woman
- Anthony Mackie: Captain America
- Sebastian Stan: The Winter Soldier
- Letitia Wright: Black Panther
- Paul Rudd: Ant-Man
- Wyatt Russell: U.S. Agent
- Tenoch Huerta Mejia: Namor
- Ebon Moss-Bachrach: The Thing
- Simu Liu: Shang-Chi
- Florence Pugh: Black Widow
- Kelsey Grammer: Beast
- Lewis Pullman: Sentry
- Danny Ramirez: Falcon
- Joseph Quinn: The Human Torch
- David Harbour: Red Guardian
- Winston Duke: M’Baku
- Hannah John-Kamen: Ghost
- Tom Hiddleston: Loki
- Patrick Stewart: Professor X
- Ian McKellen: Magneto
- Alan Cumming: Nightcrawler
- Rebecca Romijn: Mystique
- James Marsden: Cyclops
- Channing Tatum: Gambit
- Pedro Pascal: Mr. Fantastic
- Robert Downey Jr.: Iron Man/Doom
Everett K. Ross (Martin Freeman), from the Black Panther films.
Valentina Allegra de Fontaine (Julia Louis-Dreyfus), from a few things but ultimately Thunderbolts.
Although these are both secondary characters, and many secondary characters aren’t listed in general.