• 0 Posts
  • 468 Comments
Joined 5 months ago
cake
Cake day: March 31st, 2025

help-circle







  • i don’t think it would be so simple and i don’t think you can abstract neurons so hard, there are extrasynaptic receptors that react to concentrations of neurotransmitters outside synapses, and there are some neurotransmitters that leak out of synapses. thousands of leaking synapses can contribute to activation of some random receptor, or more than one this way. some other receptors are extrasynaptic by default and don’t really have synapses, neuropeptides work like this but not only these. for gasotransmitters, effectively there’s no concept of synapse. i don’t think you can abstract all neurotransmitters to some one chemical messenger either, there are different ones with different half-lives, different diffusion rates, different metabolites some of which work in completely different ways. (steroids, neuropeptides, gasotransmitters, whatever lipids go into cannabinoid system, it’s not just monoamines/glutamate/GABA/acetylcholine).

    some receptors take multiple inputs, there are NMDA receptors that really only fire when glutamate and glycine both bind to it, and only after AMPA receptor nearby opens up first. we already know these things are important in forming of memories so it’s probably a big deal. some of these receptors are ion channels, and some of these are important especially intracellular calcium








  • yeah and german toy makers were critical in supplying parts for arty fuzes in ww1. (i heard that soviet milk bottle filling machines could be repurposed for filling shells with molten explosives - both are dispensed hot, size is similar, not sure how real it is). company making complicated machinery out of many parts, requiring tight tolerances, made on-site, that already has tooling to make most of gun parts probably except barrels, makes sense that it could be pressed to make simple handguns.

    so what. manufacturing got much more specialized, so that even if in past car factory could crank out entire tanks, they probably can’t do it today easily (parts, sure, even entire engines and transmissions. not armor plate, or ceramics, or tungsten inserts or whatever these have). that factory could make stamped steel parts of jdam, but probably not much more. mk80 series shells are basically 30cm-ish wide, 1cm-ish thick steel tubes, with notches on inside and necked down while hot from both sides. can’t do that without highly specialized machinery