It’s debatable for sure. But let’s take “how did life originate” as an example. The two things we don’t know are how the first single celled lifeform came into being, and exactly how we made the jump to multicellular life. So yes, you can say “we still don’t know how life originated” but what we do know outweighs what we don’t by a lot. And our ancestors weren’t asking those two questions we still have left. I think this is actually a great example that illustrates my point. We know that all living things are connected and have a common ancestor. We know that DNA is the language of life. We know that natural selection drove its diversity, not some designer. We know that modern humans have only been on the earth for some 200k years. This really covers the questions of 01 A.D. and we’ve simply moved on to more fundamental questions. No one was asking “Okay so amino acids and lipid chains assemble spontaneously in sunlight but how do you get from that to a cell?” And that’s really all we have left to answer.

I don’t consider “what is the nature of consciousness” to be an actual question.