A treatment that blocks an age-related protein restored cartilage in aging and injured joints by reprogramming existing cells rather than using stem cells.
Researchers at Stanford Medicine report that blocking a protein linked to aging can restore cartilage that naturally wears away in the knees of older mice.
In the study, the injectable treatment not only rebuilt cartilage but also stopped arthritis from developing after knee injuries similar to ACL tears, which are common among athletes and active adults.
A pill-based version of the same therapy is already being tested in clinical trials aimed at treating muscle weakness associated with aging.
You must log in or register to comment.
It’s a small molecule inhibitor of 15-PGDH. 15-PGDH degrades prostaglandin E2. Let’s hope it works in humans too.
Original article: https://doi.org/10.1126/science.adx6649Holy cats! If that could be used for hands and finger joints.
I recently jammed my right index finger and it’s gone massively janky like insta-arthritic in the joint… swollen, hot… somewhat painful and VERY stiff. It is awful, all I can say is thank God, I’m left handed.
I have hyperflexibility and all my collagen gets made wrong, I really hope this could help my godawful knees
I need this for my right knee.
Gimme. Gimme gimme gimme.
Nice, my joints would like some. 😁
